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Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation Susan J. Hayflick, Michael C. Kruer, Allison Gregory, Tobias B. Haack, Manju A. Kurian, Henry H. Houlden, James Anderson, Nathalie Boddaert, Lynn Sanford, Sami I. Harik, Vasuki H. Dandu, Nardo Nardocci, Giovanna Zorzi, Todd Dunaway, Mark Tarnopolsky, Steven Skinner, Kenton R. Holde...
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The human pregnane X receptor (hPXR) is recognized as a xenobioticsensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A phosphomimetic mutation at threonine-290 (T290D) retained hPXR in the cytoplasm of HepG2, HuH6, and...
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The clinical efficacy of anthracyclines (e.g., doxorubicin and daunorubicin) in cancer therapy is limited by their severe cardiotoxicity, the etiology of which is still not fully understood. The development of anthracycline-induced cardiomyopathy has been found to correlate with myocardial formation and accumulation of anthracycline secondary alcohol metabolites (e.g., doxorubicinol and daunoru...
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makers such as Fraunhofer, Amici, Selligue and Chevalier? Also, the figures of the plate from the 1787 Essays on the microscope were not drawn thanks to an Adams microscope, but are copies, probably made by a camera obscura, of original figures taken from the works of Trembley (1744, 1747), Baker (1753), Rosel von Rosenhof (1755), and others. This certainly does not affect the high quality of t...
متن کاملThe Identification of the Submillimeter Galaxy Smmj00266+1708
We report the detection of 1.3mm continuum and near-infrared K−band (2.2μm) emission from the submillimeter galaxy SMMJ00266+1708. Although this galaxy is among the brightest sub-mm sources detected in the blank-sky surveys (L ∼ 10L⊙), SMMJ00266+1708 had no reliable optical/nearinfrared counter-part. We used sensitive interferometric 1.3mm observations with the Owens Valley Millimeter Array to ...
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ژورنال
عنوان ژورنال: Hispanic American Historical Review
سال: 1967
ISSN: 0018-2168,1527-1900
DOI: 10.1215/00182168-47.4.557